材料科学
光热治疗
纳米颗粒
超顺磁性
纳米技术
药物输送
磁性纳米粒子
等离子纳米粒子
等离子体子
蚀刻(微加工)
磁共振成像
光电子学
图层(电子)
磁化
磁场
物理
量子力学
医学
放射科
作者
Inmaculada Urries,Cristina Muñoz,Leyre Gómez,C. Marquina,Víctor Sebastián,Manuel Arruebo,Jesús Santamarı́a
出处
期刊:Nanoscale
[The Royal Society of Chemistry]
日期:2014-07-01
卷期号:6 (15): 9230-9230
被引量:62
摘要
PEGylated magneto-plasmonic nanoparticles with a hollow or semi-hollow interior have been successfully synthesized and their physico-chemical characteristics have been investigated. The hollow interior space can be used to store drugs or other molecules of interest whereas magnetic characterization shows their potential as contrast agents in magnetic resonance imaging (MRI) applications. In addition, their plasmonic characteristics in the near infrared (NIR) region make them efficient in photothermal applications producing high temperature gradients after short irradiation times. We show that by controlling the etching conditions the inner silica shell can be selectively dissolved to achieve a hollow or semi-hollow interior without compromising the magnetic or plasmonic characteristics of the resulting nanoparticles. Magnetic measurements and transmission electron microscopy observations have been used to demonstrate the precise control during the etching process and to select an optimal concentration of the etching reagent and contact time to preserve the inner superparamagnetic iron oxide-based nanoparticles and the plasmonic properties of the constructs. Drug loading capabilities were also evaluated for both semi-hollow and as-synthesized nanoparticles using Rhodamine B isothiocyanate as a model compound. The nanoparticles produced could be potentially used as “theranostic” nanoparticles with both imaging capabilities and a dual therapeutic function (drug delivery and hyperthermia).
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