STUDY ON THE DEVELOPMENT OF HIGH YIELDING NEOMYCINRESISTANT STRAIN OF STREPTOMYCES FRADIAE FOR IMPROVEDPRODUCTION OF NEOMYCIN BY USING OPTIMAL LEVELS OFMINERALS

We have developed an efficient high yielding neomycin resistant Strain of Streptomyces fradiae for improved production of neomycin. Streptomyces fradie was submerged in the solution of10 ug/ml, 15 ug/ml, 20 ug/ml,30 ug/ml,40 ug/ml,50 ug/ml, 60 ug/ml,70 ug/ml, 80 ug/ml, for five day for screeing out high yielding Neomycin resistant Strain of Streptomyces fradiae . Streptomyces fradie in the solution of 70 ug/ml was the high yielding Neomycin resistant Strain of Streptomyces fradiae It was same observed as prevous authors that optimal levels of the elements Ca, Fe, and Zn per milliliter of a synthetic medium for neomycin production . K2HP04 was required at a concentration of 0.1% for maximal yield of neomycin but observed improved production of neomycin. It was observed 252 ug/ml, neomycin production.