In this paper,5-bromo-isoquinoline was synthesized with one step by use isoquinoline as start material.Then a series of isoquinoline derivatives such as 5-bromo-8-nitro-isoquinoline,8-amino-isoquinoline and 8-bromo-isoquinoline were synthesized from 5-bromo-isoquinoline.All products have been confirmed by IR,NMR and so on.