Comparative Pharmacodynamic Study on Crocin-1 and Crocetin

Objective:To explore the pharmacodynamical active substances of Gardenia jasminds ELLis,the comparative pharmacodynamic study was carried out on crocin-1 and crocetin.Methods:To observe the different pharmacological influence of crocin-1 and crocetin on anti-inflammatory,blood coagulation,hepatic injury and hemorheological changes.Results:Neither crocin-1 nor crocetin has shown obvious effects of anti-inflammaory or protective effect against hepatic injury induced by CCl_4 in mice.Crocin-1 and crocetin can decrease the blood viscosity under high shear stress,and curtail prothrombin time(PT).Both medium and high concentration groups of crocetin can curtail the thrombin time and activated partial thromboplastin time(APTT).Conclusions:Neither Crocin-1 nor crocetin has shown obvious effects on anti-inflammatory,hepatic protection.Both components Can reduce the whole blood viscosity and PT significantly.Crocetin of high concentration showed strong effects on promoting coagulation than crocin-1.The results suggest that crocetin may be the substance matter of hemostasis action of fructus gardeniae.