Effect of combination of traditional Chinese medicine and lentinan on cellular immunity in patients with medium and advanced gastric cancer

Objective To investigate the effect of combination of traditional Chinese medicine and lentinan on cellular immunity in patients with medium and advanced gastric cancer. Methods 47 patients with medium and advanced gastric cancer were randomly divided into two groups. Patients in lentinan group (n=24) were treated by lentinan. 23 cases in traditional Chinese medicine combined with lentinan group were treated by combination of traditional Chinese medicine and lentinan. The changes of cellular immunity were observed after two weeks.Results NK cell, CD3 and CD4 was increased compared with those before treatment in traditional Chinese medicine combined with lentinan group (P0.05). CD3 and CD4 was decreased compared with those before treatment in lentinan group (P0.05). NK was decreased, CD4 was increased compared with those in lentinan group after treatment (P0.05). Syndromes of traditional Chinese medicine score were decreased compared with those before treatment in traditional Chinese medicine combined with lentinan group (P0.05).Conclusion The combination of traditional Chinese medicine and lentinan can increase ratio of CD3 and CD4 in patients with medium and advanced gastric cancer, and raise NK cell for improvement of cellular immunity.