The liver has great regeneration capacity.As a response to injury(partial hepatectomy,injury by chemical toxins and virus),liver regeneration is stimulated to repair the damaged tissue and rival injury by.proliferation and differentiation of parenchymal cell and nonparenchymal cell.Liver regeneration is a complicated and special process of cell proliferation,its regulatory mechanism is also very complicated.So in this review,we discuss these aspects of liver regeneration.