In this paper,the capabilities of starch-based adhesive modified by hexamethoxy-methylmelamine were studied.The result showed that a etherization reaction was occurred between hexamethoxy-methylmelamine and starch.The optimum dosage of hexamethoxy-methylmelamine and catalyzer were 7mL and 0.3g for 100g adhesive,and the optimum reacting temperature and reacting time were 65℃and 1h respectively.Particleboards prepared with an optimal adhesive formulation exhibited good water resistance and internal bond strength while the fluidity of the starch-based adhesive remained in a good level.