三氟甲基
丙二酸
水解
化学
介子
产量(工程)
组合化学
有机化学
材料科学
冶金
烷基
作者
Y. X. Liu,Xiangqiao Yang,Tong Lin,Guantian Yang,Xiaoyong Xu,Bu‐Bing Zeng,Zhong Li,Weiping Zhu,Xuhong Qian
标识
DOI:10.1016/j.cclet.2024.109747
摘要
Triflumezopyrim (TFM) is a novel mesoionic pyrido[1,2-α]pyrimidinones insecticide, which acts on nicotinic acetylcholine receptors (nAChRs) and has no cross-resistance with other insecticides. Herein, we firstly developed a new continuous flow approach to synthesis 2-[3-(trifluoromethyl)phenyl]malonic acid, a key intermate of TFM, coupling with esterification, condensation, and hydrolysis. All three-step reactions were optimized and transformed into a continuous synthesis mode by three micro reaction units. Compared with the batch mode, the total reaction time and overall separation yield were improved from more than 12 h and 60% to 18 minutes and 73.38%, respectively. The solvent consumption and waste emission were significantly reduced, which also provides an eco-friendly and efficient potential tool for the development and production of mesoionic pyrido[1,2-α]pyrimidinones insecticide.
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