Association of glycosylated hemoglobin concentrations with structural and functional brain changes in the normoglycemic population: A systematic review

部分各向异性 人口 大脑结构与功能 神经影像学 大脑大小 痴呆 认知 高强度 心理学 医学 临床心理学 白质 神经科学 内科学 磁共振成像 疾病 环境卫生 放射科
作者
Yunus Soleymani,Seyed Amir Hossein Batouli,Amin Akbari Ahangar,Ata Pourabbasi
出处
期刊:Journal of Neuroendocrinology [Wiley]
被引量:1
标识
DOI:10.1111/jne.13437
摘要

Abstract Optimal glucose control is crucial for maintaining brain health and preventing metabolic and cognitive disorders in the general population. Glycosylated hemoglobin (HbA1c) serves as a key marker for assessing glucose intolerance and its impact on brain structure and function in healthy individuals. However, existing literature presents conflicting findings, necessitating a systematic review to consolidate current knowledge in this domain. This systematic review examines 26 English‐language studies involving participants aged 15 years and above, investigating the relationship between HbA1c levels and brain health. Studies focusing on normal/general populations and utilizing magnetic resonance imaging (MRI) as the imaging modality were included. Exclusion criteria encompassed review articles, abstracts, letters, animal studies, and research involving neuropsychiatric or metabolic diseases. Data were gathered from PubMed, Scopus, and Web of Science databases up to November 2023. Analysis reveals significant associations between HbA1c levels and various brain metrics, including volume, cortical thickness, fractional anisotropy, mean diffusivity, activity, and connectivity. However, findings exhibit inconsistency, likely attributed to disparities in sample characteristics and study sizes. Notably, hippocampal volume, white matter hyperintensity, and ventral attention network connectivity emerge as frequently affected structures and functions, mirroring trends observed in diabetic populations. Despite inconclusive evidence, glucose intolerance appears to exert considerable influence on select brain structures and functions in individuals without diagnosed metabolic disorders. Understanding these associations is critical for mitigating the risk of cognitive decline and dementia in healthy populations. Future investigations should aim to elucidate the intricate relationship between HbA1c concentrations and brain health parameters in normoglycemic individuals.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
淡水痕发布了新的文献求助10
1秒前
1秒前
1秒前
zc发布了新的文献求助10
2秒前
2秒前
研友_VZG7GZ应助Yuanyuan采纳,获得10
2秒前
zzzzzz完成签到,获得积分10
3秒前
小太阳完成签到,获得积分10
3秒前
3秒前
4秒前
追寻夜白完成签到,获得积分10
4秒前
酒笙发布了新的文献求助10
5秒前
DLQ完成签到,获得积分10
5秒前
6秒前
6秒前
7秒前
7秒前
科研通AI5应助初学者采纳,获得10
7秒前
研友_VZG7GZ应助嘎嘎采纳,获得10
7秒前
北栀发布了新的文献求助10
8秒前
8秒前
一只半夏完成签到,获得积分10
9秒前
研友_nv4Bx8完成签到,获得积分10
9秒前
大个应助wt采纳,获得10
9秒前
所所应助老八采纳,获得10
9秒前
10秒前
10秒前
胖胖玩啊玩完成签到 ,获得积分10
10秒前
华仔应助王珂采纳,获得10
10秒前
结实的青荷完成签到,获得积分10
11秒前
11秒前
爆米花应助简单以宁2采纳,获得10
13秒前
14秒前
15秒前
shadow完成签到,获得积分10
15秒前
16秒前
17秒前
18秒前
Benjamin完成签到,获得积分10
18秒前
花痴的翠容完成签到,获得积分10
19秒前
高分求助中
Thinking Small and Large 500
Algorithmic Mathematics in Machine Learning 500
Handbook of Innovations in Political Psychology 400
Mapping the Stars: Celebrity, Metonymy, and the Networked Politics of Identity 400
Visceral obesity is associated with clinical and inflammatory features of asthma: A prospective cohort study 300
Getting Published in SSCI Journals: 200+ Questions and Answers for Absolute Beginners 300
Engineering the boosting of the magnetic Purcell factor with a composite structure based on nanodisk and ring resonators 240
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3838631
求助须知:如何正确求助?哪些是违规求助? 3380977
关于积分的说明 10516656
捐赠科研通 3100565
什么是DOI,文献DOI怎么找? 1707592
邀请新用户注册赠送积分活动 821803
科研通“疑难数据库(出版商)”最低求助积分说明 772980