细菌
抗菌活性
抗生素
细菌细胞结构
胶体金
纳米技术
纳米颗粒
体内
化学
致病菌
材料科学
微生物学
生物
生物化学
遗传学
生物技术
作者
Le Wang,Wenfu Zheng,Sixiang Li,Leni Zhong,Xingyu Jiang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2022-04-29
卷期号:22 (9): 3576-3582
被引量:25
标识
DOI:10.1021/acs.nanolett.1c04968
摘要
Nanomaterials usually kill bacteria via multiple mechanisms which are not explicit to the same degree as those of conventional antibiotics. This situation may hinder the development of novel nanoscale antibiotics. Here, we present aminophenol (AP) to modify gold nanoparticles (AP_Au NPs) which show a broad antibacterial spectrum and potent antibacterial effects against multidrug-resistant (MDR) bacteria with clear antibacterial mechanisms. AP_Au NPs can not only damage bacterial cell walls but also bind to the 16S rRNA to block bacterial protein synthesis. Moreover, AP_Au NPs show excellent performance in curing abdominal bacterial infections in an in vivo model. AP_Au NPs thus have the potential to become a novel antibacterial agent for clinical applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI