肿瘤微环境
癌症
免疫疗法
免疫系统
疾病
雄激素受体
生物
免疫
癌症免疫疗法
免疫学
雄激素
获得性免疫系统
前列腺癌
生物信息学
内科学
医学
激素
内分泌学
遗传学
作者
Johanna M. Schafer,Tong Xiao,Hyun-Wung Kwon,Katharine A. Collier,Yuzhou Chang,Hany A. Abdel-Hafiz,Chelsea Bolyard,Dongjun Chung,Yuanquan Yang,Debasish Sundi,Qin Ma,Dan Theodorescu,Xue Li,Zihai Li
出处
期刊:iScience
[Elsevier]
日期:2022-08-01
卷期号:25 (8): 104717-104717
被引量:12
标识
DOI:10.1016/j.isci.2022.104717
摘要
The cancer research field is finally starting to unravel the mystery behind why males have a higher incidence and mortality rate than females for nearly all cancer types of the non-reproductive systems. Here, we explain how sex - specifically sex chromosomes and sex hormones - drives differential adaptive immunity across immune-related disease states including cancer, and why males are consequently more predisposed to tumor development. We highlight emerging data on the roles of cell-intrinsic androgen receptors in driving CD8+ T cell dysfunction or exhaustion in the tumor microenvironment and summarize ongoing clinical efforts to determine the impact of androgen blockade on cancer immunotherapy. Finally, we outline a framework for future research in cancer biology and immuno-oncology, underscoring the importance of a holistic research approach to understanding the mechanisms of sex dimorphisms in cancer, so sex will be considered as an imperative factor for guiding treatment decisions in the future.
科研通智能强力驱动
Strongly Powered by AbleSci AI