[Connective tissue diseases and the liver injury].

Connective tissue disease (CTD) are closely related to liver abnormality. CTD can affect the liver causing various degrees of liver injury, coexist with other liver diseases, especially autoimmune liver disease (ALD). Medications for CTD can also lead to liver injury or reactivate the hepatitis B virus. CTD patients can also be positive for ALD-related autoantibodies without corresponding manifestation; and vis versa. The diagnosis and differential diagnosis should be made on integrating clinical presentation, laboratory, imaging, and histological studies, not solely relying on autoantibody positivity.结缔组织病（CTD）与肝脏关系密切。CTD可以累及肝脏并导致不同程度的肝损伤，也可以合并其他肝脏疾病尤其是自身免疫性肝脏疾病（ALD）。此外，治疗CTD的药物也可以引起肝脏损伤或激活乙型肝炎病毒。需要注意的是，ALD可出现CTD相关的自身抗体阳性，而无CTD的其他表现；反之亦然。因此，其诊断和鉴别诊断需综合分析患者的临床表现、实验室检查、影像学检查，甚至组织病理学检查，不能仅凭相应的自身抗体阳性就下结论。.