New 1,4-Dihydropyridines. Optimization of the Synthesis and In Silico Analysis of Biological Activity

Abstract An efficient procedure has been developed for the synthesis of 1,4-dihydropyridines containing aliphatic and 2-(1-hydroxycyclopropyl)methyl substituents via multicomponent Hantzsch reaction using europium(III) chloride hexahydrate as catalyst. The synthesized compounds were evaluated for their potential biological activity by simulation of phospholipid bilayer permeability and molecular docking against human protein kinase and cytochrome P450. Study of the effect of the synthesized compounds on the growth of the yeasts Yarrowia lipolytica and Saccharomyces cerevisiae showed the absence of acute toxicity.