类有机物
3D生物打印
肿瘤微环境
计算机科学
计算生物学
肿瘤细胞
生物
癌症研究
组织工程
神经科学
遗传学
作者
Xiaoyu Wang,Yixue Luo,Yue Ma,Pengyu Wang,Rui Yao
标识
DOI:10.1016/j.tibtech.2023.11.006
摘要
Bioprinting shows excellent potential for preclinical tumor modeling, with significant advantages over 2D cell cultures in replicating the tumor microenvironment (TME). Recently, the use of tumor organoids in bioprinting models has emerged as a groundbreaking approach to simulate volumetric tumor tissues. This synergetic fabrication method leverages the advantages of the spatial and geometric control of bioprinting to assemble heterogeneous TME components, while tumor organoids maintain collective cell behaviors. In this review, we provide a landscape of the latest progress on the convergence of 3D bioprinting and tumor organoids. Furthermore, we discuss the potential to incorporate organ-on-a-chip with bioprinting tumor organoids to improve the biomimicry and predictability of therapeutic performance. Lastly, we address the challenges to personalized medicine and predictive clinical integration.
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