Regioselective C‐9 Arylation of Evodiamine via Bromination and Suzuki Coupling

ABSTRACT A series of 9‐aryl evodiamine derivatives were successfully synthesized in moderate yields via a two‐step, regioselective process involving 9‐bromination with Br 2 followed by Suzuki coupling with various arylboronic acids. The structures of the compounds were confirmed by 1 H NMR, 13 C NMR, and HRMS analysis.