A copper sulfide/glucose oxidase/elesclomol nanoplatform for photothermal enhanced copper-induced toxicity/chemodynamic tumor combination therapy

into the tumor microenvironment (TME), where it binds to the copper ion carrier ES for targeted delivery to tumor cells, inducing copper-induced toxicity and tumor cell death. The CuS@GOx@ES nanoplatform effectively combines CDT, PTT, ST, and copper-induced toxicity, creating a synergistic effect where the treatments enhance each other to achieve superior therapeutic outcomes.