Enantiomer separation of amino acid derivatives on a new polymeric chiral resorc[4]arene stationary phase by capillary gas chromatography

A new resorc[4]arene basket-type selector containing chiral diamide groups was synthesized and bonded to a dimethylpolysiloxane backbone. Fifteen proteinogenic amino acids could be separated into their enantiomers as N(O,S)-trifluoroacetylmethyl esters. The new stationary phase exhibited excellent column efficiency above 100°C and thermal stability up to 200°C.