Molecular and Cellular Actions of g-Hydroxybutyric Acid: Possible Mechanisms Underlying GHB Efficacy in Narcolepsy

Initial evaluation of GHB in animals and humans explored its sleep-promoting, and anesthesia-inducing capacity. This substance was recognized to preferentially promote non-rapid eye movement sleep (NREM, or slow-wave deep sleep), and facilitate sleep consolidation. These properties led to the exploration of its utility in a variety of clinical indications. In particular, the majority of recent therapeutic research has focused on narcolepsy.