Fabrication of Electrochemical Sensor Based on Layered Double Hydroxide/Polypyrrole/Carbon Paste for Determination of an Alpha‐adrenergic Blocking Agent Terazosin

Abstract New insights into the design of highly sensitive, carbon‐based electrochemical sensors are presented in this work. This was achieved by exploring the interesting properties of conductive (Mg/Al) layered double hydroxide‐dodecyl sulphate/polypyrrole nanocomposites which were synthesized by in‐situ polymerization of pyrrole during the assembly of (Mg/Al) layered double hydroxide, and by employing the anionic surfactant dodecyl sulphate as a modifier. Changes in morphology and surface area of the nanocomposites occured as a result of change in pyrrole percentage. Under optimal conditions, the modified carbon paste electrode successfully achieved detection limits of 0.057 and 0.134 nmol L −1 of Terazosin hydrochloride in pharmaceutical formulation and spiked human serum fluid, respectively. Moreover, the sensors are highly stable, reusable and free of interference by other commonly present excipients in drug formulations.