[The effect of cytokines on myelopoiesis. Origin, regulation of secretion and biological activity].

Recombinant DNA technology has been central in answering some of the most relevant questions in research of the regulation of the functional status of hematopoietic progenitor cells and their progney. This article focuses on recent results that have emerged from studies utilizing recombinant growth factor molecules regulating hemopoietic blood cell development and activation. The following points are considered: biological characteristics of hemopoietic growth factors and synergizing factors, their role in the regulation of hemopoiesis and activation of normal and leukemic cells, their cellular origin, and regulation of production.