伤口愈合
吲哚青绿
光热治疗
生物膜
排尿
生物相容性
材料科学
生物医学工程
外科
化学
医学
纳米技术
泌尿系统
生物
内分泌学
有机化学
细菌
遗传学
作者
Die Dong,Rimei Chen,Jia Ji-hong,Chao Zhao,Zhiping Chen,Qin Lu,Yupei Sun,Weixin Huang,Chunfang Wang,Yao Li,Hui He
标识
DOI:10.1016/j.carbpol.2023.120542
摘要
The rapid loss of drugs and the weak curative effects due to cyclical urination are the main reasons why wound heal with difficulty after bladder tumour resection. Here, a bioinspired cellulose nanofibre (CNF)-based magnetic 3D nanonetwork wound dressing with excellent tissue adhesion and biocompatibility is designed by the assembly of pH- and near infrared-responsive CNF nanoskeletons, magnetic switching Fe3O4 nanoparticles, and temperature switching Pluronic®F-127. The dressing with high loading capacity for mitomycin and indocyanine green can form a sticky 3D nanonetwork at the wound site and remain for a long time to release drugs through an external magnetic field. Interestingly, the dressing possessed excellent antibacterial activity, bacterial biofilm elimination, T24 tumour cell killing, and wound healing promotion through photothermal, photodynamic, and chemotherapy. Therefore, it has promising application for bladder postoperative infected wound healing to avoid rapid loss of drugs due to cyclical urination.
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