Chlorella-Loaded Bioglue with Antibacterial, Antioxidant, and Immunomodulatory Properties for Accelerated Wound Healing

Biological glue (bioglue) can noninvasively seal and reattach wound tissue outside the hospital, which has been extensively studied recently. Nevertheless, the commercial bioglue lacks constant oxygen supply, antioxidation, and anti-inflammation, three other key factors for bacteria-infected wound healing in plateau areas. Herein, a multifunctional bioglue (LA-DESP/ε-PLL@Chlorella) is simply fabricated by encapsulating Chlorella into a matrix composed of α-lipoic acid (LA), α-lipoic acid sodium (LANa), and ε-polylysine (ε-PLL). In vitro studies depicted that the LA-DESP/ε-PLL@Chlorella bioglue exhibits good adhesion, oxygen delivery, antioxidant, antibacterial, antibiofilm, and anti-inflammatory activities. Furthermore, in vivo experiments show that LA-DESP/ε-PLL@Chlorella bioglue could eradicate bacteria, reduce inflammation, and promote the healing of bacteria-infected wound. This multifunctional bioglue represents a promising concept and alternative therapeutic option for accelerating the healing of bacteria-infected wounds.