生物
染色体不稳定性
遗传学
染色体
基因组不稳定性
基因组
胚胎
核型
细胞遗传学
基因
DNA
DNA损伤
作者
Giulia Vitetta,Laura Desiderio,Ilaria Baccolini,Vera Uliana,Giulia Lanzoni,T. Ghi,Gianluigi Pilu,Enrico Ambrosini,Patrizia Caggiati,Valeria Barili,Anna Maria Trotta,Maria Rosaria Liuti,Elisabetta Malpezzi,Maria Carla Pittalis,Antonio Percesepe
标识
DOI:10.1186/s13039-024-00675-3
摘要
Mosaic chromosomal anomalies arising in the product of conception and the final fetal chromosomal arrangement are expression of complex biological mechanisms. The rescue of unbalanced chromosome with selection of the most viable cell line/s in the embryo and the unfavourable imbalances in placental tissues was documented in our previous paper and in the literature. We report four additional cases with mosaic derivative chromosomes in different feto-placental tissues, further showing the instability of an intermediate gross imbalance as a frequent mechanism of de novo cryptic deletions and duplications. In conclusion we underline how the extensive remodeling of unbalanced chromosomes in placental tissues represents the 'backstage' of de novo structural rearrangements, as the early phases of a long selection process that the genome undergo during embryogenesis.
科研通智能强力驱动
Strongly Powered by AbleSci AI