Versatile Fluorinated Building Blocks by Stereoselective (Per)fluoroalkenylation of Ketones

The synthesis of fluorinated compounds is of increasing importance for the preparation of new pharmaceuticals and agrochemicals. For this purpose, the development of general and selective synthetic methods, which allow the preparation of versatile and scalable building blocks, is required. In this respect, here we report a facile and practical method for the stereoselective synthesis of fluoroalkylated β‐fluoroenones from ubiquitous ketones. The presented transition‐metal‐free procedure makes use of an amine promoter and easily available starting materials. It features broad substrate diversity with excellent stereoselectivity. In general, this novel strategy provides a facile synthesis of structurally diverse (per)fluoroalkylated β‐fluoroenones, which can be further transformed to various potentially bioactive molecules in a straightforward manner.