PM2.5 bound phthalates in four metropolitan cities of China: Concentration, seasonal pattern and health risk via inhalation

Phthalates (PAEs) are in a group of artificial chemicals with potential adverse effects to human health and they can be frequently detected in environmental matrices due to its extensive usage. However, seasonal patterns of concentrations in atmosphere and risks posed by PAEs in airborne PM2.5 to Chinese population have not been well characterized. During the period of November 2015 to March 2017, samples of fine particulate matter (PM2.5) were collected in four cities of Guangzhou, Shanghai, Beijing and Harbin, which are major metropolitan areas of various latitudes of China. Concentrations of fourteen PAEs in airborne PM2.5 were quantified using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Estimated daily intakes (EDIs), hazard quotients (HQs) and hazard index (HI) were calculated. Lifetime average daily doses (LADD) and incremental lifetime cancer risks (ILCR) of di(2-ethylhexyl) phthalate (DEHP) for four age groups, which divide with infant, toddler, adolescent and adult, by inhalation route were evaluated. Dimethyl phthalate (DMP), Diethyl phthalate (DEP), Di-n-butyl phthalate (DBP), and DEHP were the four major PAEs contaminants in these PM2.5 samples. The sum concentrations of DMP, DEP, DBP and DEHP in Guangzhou, Shanghai, Beijing and Harbin ranged from 32.5-76.1, 10.1-101, 8.02-107 and 13.5-622 ng/m3, with mean concentrations of 59.1, 50.8, 43.8 and 136 ng/m3, respectively. The concentration of total PAEs in PM2.5 from higher latitudes city (Harbin) was higher than those from lower latitudes cities (Guangzhou and Shanghai). Total concentrations of PAEs were significantly higher during warmer seasons than those during colder seasons among the four cities. Although the EDIs, HQs, and HI for all age groups were less than the threshold set by the U.S. Environmental Protection Agency (US EPA) and European Food Safety Authority (EFSA), the highest values of 70-years ILCR from Shanghai and Harbin were 1.2 × 10-6 and 1.3 × 10-6, which were slightly beyond the acceptable level of 10-6. These findings reveal that the cancer risks of DEHP bound to PM2.5 in these two cites should be of particular concern.