同源重组
DNA修复
生物
DNA连接酶
DNA
同源染色体
DNA损伤
遗传学
基因组不稳定性
泛素
泛素连接酶
细胞生物学
基因组
计算生物学
作者
Xuanpeng Wang,Lili Wang,Yongchi Huang,Zhiping Deng,Cunliang Li,Jian Zhang,Mingxi Zheng,Shunping Yan
标识
DOI:10.1073/pnas.2202970119
摘要
SignificanceDNA damage causes genome instability and numerous diseases including cancers. Homologous recombination repair (HR) is an error-free pathway to repair DNA double-strand breaks, the most serious forms of DNA damage. However, the HR mechanisms in plants are still poorly understood. The transcription factor SOG1 is a master regulator of plant DNA damage responses. In this study, we find that a plant-specific ubiquitin E3 ligase DDRM1 ubiquitinates and stabilizes SOG1 to promote HR. Therefore, DDRM1- SOG1 is a plant-specific module for HR. DDRM1 is an evolutionarily ancient protein, which is identified in mosses, the first land plants, indicating that DNA damage response is an important mechanism for plant evolution from aquatic to land.
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