结肠炎
封堵器
厚壁菌
硒
氧化应激
体内
化学
胃肠病学
微生物学
生物化学
食品科学
生物
免疫学
紧密连接
医学
生物技术
基因
16S核糖体RNA
有机化学
作者
Hongyan Li,Hongxia Che,Jingwen Xie,Xiufang Dong,Lin Song,Wancui Xie,Jinyuan Sun
标识
DOI:10.1016/j.ijbiomac.2021.11.189
摘要
The deficiency of selenium has been found in clinical IBD patients and supplementation selenium is recognized as beneficial for colitis treatment. In this study, an organic selenium compound-selenylation α-D-1,6-glucan (sCPA) was prepared, and the effect of sCPA on DSS induced colitis mice was investigated. The results suggested that sCPA prevented the weight loss, colon length shortening, and stool loose of colitis mice. It protected colon mucosal barrier by promoting tight junction protein ZO-1 and Occludin expression. Moreover, sCPA reduced oxidative stress via regulating SOD and MDA levels, and decreased the contents of inflammatory proteins NF-κB and NLRP3 and adjusted TNF-α, IFN-γ, IL-1β, and IL-10 inflammatory cytokines. Furthermore, sCPA repaired intestinal microbiota composition especially Bacteroidetes, Firmicutes, Proteobacteria, and Actinobacteria that altered by DSS in colitis mice. Meanwhile, SCFAs produced by gut microbiota were restored by sCPA close to the level in the normal group. In conclusion, these findings indicated that the sCPA might be a potential dietary selenium supplementation for the prevention and treatment of colitis.
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