Granisetron Versus Pethidine in Treatment of Post Spinal Shivering in Cesarean Sections

Abstract Background Shivering can be defined as spontaneous, rhythmic, oscillatory, tremor like muscular hyperactivity which occurs as a physiological stressful response to core .hypothermia in an attempt to raise the metabolic heat production Objective To compare between granisetron and pethidine in treatment of post spinal .shivering in cesarean sections Methods This prospective randomized controlled study was conducted in Ain Shams University Hospitals, Cairo Egypt on 330 patients listed for elective cesarean sections within .a period of 6 months Results Groups were comparable in demographic data (in terms of age, medical status and BMI) and there were no statistically significant difference between groups. Groups were comparable in preoperative vital data (in terms of oxgyn saturation, mean arterial blood pressure, heart rate and temperature temp) and there were no statistically significant difference between groups. Groups were comparable in postoperative vital data (in terms of oxgyn saturation, mean arterial blood pressure, heart rate and temperature) at 10 min intervals in PACU for 30 min and there were no statistically significant difference between groups. Groups were compared in shivering as regard (degree of shivering before and after treatment and recurrence) and there were statistically significant difference between groups of degree of shivering after treatment. Paired data is done for both groups to degree of shivering post and pre treatment and both groups showed significant decrease of shivering degree before and after treatment. Groups were compared in post operative nausea and vomiting and there were statistically significant difference between groups. Groups were compared in post operative .pain after spinal subside and there were statistically significant difference between groups Conclusion Both drugs are effective in treatment of post spinal shivering further pethidine is more effective as it showed less degree of shivering postoperative, and was superior in postoperative pain score. Granisetron was also effective and superior in .postoperative nausea and vomiting prevention