血管生成
肿瘤微环境
癌症研究
转移
肿瘤进展
限制
信号转导
医学
生物
癌症
肿瘤细胞
细胞生物学
遗传学
机械工程
工程类
作者
Sara M. Weis,David A. Cheresh
出处
期刊:Nature Medicine
[Springer Nature]
日期:2011-11-01
卷期号:17 (11): 1359-1370
被引量:1519
摘要
As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated angiogenesis is a promising tactic in limiting cancer progression. The tumor microenvironment comprises numerous signaling molecules and pathways that influence the angiogenic response. Understanding how these components functionally interact as angiogenic stimuli or as repressors and how mechanisms of resistance arise is required for the identification of new therapeutic strategies. Achieving a durable and efficient antiangiogenic response will require approaches to simultaneously or sequentially target multiple aspects of the tumor microenvironment.
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