Cholesterol-dependent control of endosomal escape regulates intracellular trafficking of small interfering RNA therapeutics and interactions with small molecule drugs

This dataset includes raw and processed measurements examining how modulation of intracellular cholesterol alters the efficacy of FDA-approved siRNA therapeutics. Data are structured according to experimental variables, including cell model, cholesterol manipulation strategy, siRNA treatment, and target suppression quantified at both the mRNA and protein levels.