干细胞
造血
祖细胞
雌激素
生物
细胞生物学
诱导多能干细胞
利基
内分泌系统
激素
胚胎干细胞
内分泌学
遗传学
生物化学
基因
作者
Hye-Ryeon Heo,Li Chen,Borim An,Kye-Seong Kim,Junfeng Ji,Seok‐Ho Hong
标识
DOI:10.15283/ijsc.2015.8.1.18
摘要
Self-renewal and differentiation are hallmarks of stem cells and controlled by various intrinsic and extrinsic factors. Increasing evidence indicates that estrogen (E2), the primary female sex hormone, is involved in regulating the proliferation and lineage commitment of adult and pluripotent stem cells as well as modulating the stem cell niche. Thus, a detailed understanding of the role of E2 in behavior of stem cells may help to improve their therapeutic potential. Recently, it has been reported that E2 promotes cell cycle activity of hematopoietic stem and progenitor cells and induces them to megakaryocyte-erythroid progenitors during pregnancy. This study paves the way towards a previously unexplored endocrine mechanism that controls stem cell behavior. In this review, we will focus on the scientific findings regarding the regulatory effects of E2 on the hematopoietic system including its microenvironment.
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