多不饱和脂肪酸
成骨细胞
内分泌学
内科学
骨重建
化学
体内
碱性磷酸酶
骨细胞
离体
前列腺素E2
体外
生物
生物化学
医学
脂肪酸
酶
生物技术
作者
Bruce A. Watkins,Yong Li,Hugh E. Lippman,Shizhe Feng
标识
DOI:10.1016/s0952-3278(03)00063-2
摘要
Recent investigations indicate that the type and amount of polyunsaturated fatty acids (PUFA) influence bone formation in animal models and osteoblastic cell functions in culture. In growing rats, supplementing the diet with omega-3 PUFA results in greater bone formation rates and moderates ex vivo prostaglandin E(2) production in bone organ cultures. A protective effect of omega-3 PUFA on minimizing bone mineral loss in ovariectomized rats has also been reported. The actions of omega-3 fatty acids on bone formation appear to be linked to altering osteoblast functions. Herein we describe experiments with MC3T3-E1 osteoblast-like cells that support findings in vivo where omega-3 PUFA modulated COX-2 protein expression, reduced prostaglandin E(2) production, and increased alkaline phosphatase activity. Other studies indicate that the dietary source of PUFA may affect protein expression of Cbfa1 and nodule formation in fetal rat calvarial cells.
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