医学
芦荟
糖尿病足溃疡
随机对照试验
坏疽
安慰剂
内科学
临床试验
外科
糖尿病足
截肢
检查表
糖尿病
传统医学
病理
认知心理学
替代医学
内分泌学
心理学
作者
Younes Najafian,Zahra Mazloum Khorasani,Mona Najaf Najafi,Shokouh Sadat Hamedi,Marjan Mahjour,Zohre Feyzabadi
出处
期刊:Current Drug Discovery Technologies
[Bentham Science]
日期:2019-06-24
卷期号:16 (2): 223-231
被引量:23
标识
DOI:10.2174/1570163815666180115093007
摘要
Background: Diabetic foot ulcer (DFU) is one of the most common complications of diabetic patients. Mostly, non-healing DFU leads to infection, gangrene, amputation and even death. High costs and poor healing of the wounds need a new treatment such as alternative medicine. So, the aim of this study was to evaluate the efficacy of Aloe vera/ Plantago major gel (Plantavera gel) in healing of DFU Methods: Forty patients with DFU enrolled in a double-blind randomized clinical trial. The patients who were randomly assigned into the intervention group (n = 20), received topical Plantavera gel in addition to the routine cares, whereas the patients in the control group (n = 20), received topical Placebo gel in addition to the routine cares. Intervention was done twice a day for 4 weeks in the both groups. Photography and an evaluation of DFU healing were conducted by a checklist and then were scored at baseline and at the end of each week. The collected data was analyzed by SPSS software. Results: At the end of the study, there was a significant difference between the two groups in terms of total ulcer score (P<0.001) and Plantavera gel significantly reduced the ulcer surface comparing with the control group (P=0.039). However, there was not a significant difference between the two groups (P=0.263) in terms of the ulcer depth. During this study, no side effect was observed for Plantavera gel in the intervention group. Conclusion: Topical Plantavera gel seems to be an effective, cheap and safe treatment. Of course, further studies are required to confirm the properties of the wound healing of this gel.
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