降解体
新月形茎杆菌
核糖核酸
外小体复合体
生物
核糖体
核糖核酸酶P
细胞生物学
抄写(语言学)
核糖核蛋白
RNA解旋酶A
小核RNA
RNA依赖性RNA聚合酶
生物化学
解旋酶
基因
语言学
哲学
细菌蛋白
作者
Agamemnon J. Carpousis,Nathalie Campo,Lydia Hadjeras,Lina Hamouche
出处
期刊:Annual Review of Microbiology
[Annual Reviews]
日期:2022-09-08
卷期号:76 (1): 533-552
被引量:4
标识
DOI:10.1146/annurev-micro-041020-113308
摘要
RNA degradosomes are multienzyme complexes composed of ribonucleases, RNA helicases, and metabolic enzymes. RNase E-based degradosomes are widespread in Proteobacteria. The Escherichia coli RNA degradosome is sequestered from transcription in the nucleoid and translation in the cytoplasm by localization to the inner cytoplasmic membrane, where it forms short-lived clusters that are proposed to be sites of mRNA degradation. In Caulobacter crescentus, RNA degradosomes localize to ribonucleoprotein condensates in the interior of the cell [bacterial ribonucleoprotein-bodies (BR-bodies)], which have been proposed to drive the concerted degradation of mRNA to nucleotides. The turnover of mRNA in growing cells is important for maintaining pools of nucleotides for transcription and DNA replication.Membrane attachment of the E. coli RNA degradosome is necessary to avoid wasteful degradation of intermediates in ribosome assembly. Sequestering RNA degradosomes to C. crescentus BR-bodies, which exclude structured RNA, could have a similar role in protecting intermediates in ribosome assembly from degradation.
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