蜕膜化
细胞生物学
成纤维细胞
生物
内分泌学
间质细胞
内科学
蜕膜细胞
化学
胚胎
癌症研究
体外
生物化学
胎盘
胎儿
医学
遗传学
怀孕
作者
Si-Ting Chen,Wenwen Shi,Yu-Qian Lin,Zeng-Ming Yang,Ying Wang,Mengyuan Li,Yue Li,Aixia Liu,Yali Hu,Zeng‐Ming Yang
出处
期刊:eLife
[eLife Sciences Publications, Ltd.]
日期:2023-07-17
卷期号:12
摘要
Decidualization is a process in which endometrial stromal fibroblasts differentiate into specialized secretory decidual cells and essential for the successful establishment of pregnancy. The underlying mechanism during decidualization still remains poorly defined. Because decidualization and fibroblast activation share similar characteristics, this study was to examine whether fibroblast activation is involved in decidualization. In our study, fibroblast activation-related markers are obviously detected in pregnant decidua and under in vitro decidualization. ACTIVIN A secreted under fibroblast activation promotes in vitro decidualization. We showed that arachidonic acid released from uterine luminal epithelium can induce fibroblast activation and decidualization through PGI2 and its nuclear receptor PPARδ. Based on the significant difference of fibroblast activation-related markers between pregnant and pseudopregnant mice, we found that embryo-derived TNF promotes CPLA2α phosphorylation and arachidonic acid release from luminal epithelium. Fibroblast activation is also detected under human in vitro decidualization. Similar arachidonic acid-PGI2-PPARδ-ACTIVIN A pathway is conserved in human endometrium. Collectively, our data indicate that embryo-derived TNF promotes CPLA2α phosphorylation and arachidonic acid release from luminal epithelium to induce fibroblast activation and decidualization.
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