生物膜
光热治疗
微生物学
细菌
炎症
金黄色葡萄球菌
抗菌剂
光热效应
巨噬细胞极化
化学
体内
巨噬细胞
材料科学
体外
纳米技术
生物
免疫学
生物化学
遗传学
生物技术
作者
Meng Ding,Yu Zhang,Xiaoye Li,Qiang Li,Weijun Xiu,Ao He,Zhuo Dai,Heng Dong,Jingyang Shan,Yongbin Mou
出处
期刊:Small
[Wiley]
日期:2024-05-10
标识
DOI:10.1002/smll.202400927
摘要
Abstract Due to the presence of spatial barriers, persistent bacteria, and excessive inflammation in bacteria biofilm‐infected wounds, current nanoplatforms cannot effectively address these issues simultaneously during the therapeutic process. Herein, a novel biomimetic photothermal nanoplatform integrating silver and polydopamine nanoparticles (Ag/PDAs) that can damage biofilms, kill bacterial persisters, and reduce inflammation for wound treatment is presented. These findings reveal that Ag/PDAs exhibit a broad‐spectrum antimicrobial activity through direct damage to the bacterial membrane structure. Additionally, Ag/PDAs demonstrate a potent photothermal conversion efficiency. When combined with near‐infrared (NIR) irradiation, Ag/PDAs effectively disrupt the spatial structure of biofilms and synergistically eradicate the resident bacteria. Furthermore, Ag/PDAs show remarkable anti‐inflammatory properties in counteracting bacterium‐induced macrophage polarization. The in vivo results confirm that the topical application of Ag/PDAs significantly suppress Staphylococcus aureus biofilm‐infected wounds in murine models, concurrently facilitating wound healing. This research provides a promising avenue for the eradication of bacterial biofilms and the treatment of biofilm‐infected wounds.
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