CDKN2A
生物
遗传学
癌症研究
单核苷酸多态性
种系突变
外显子组测序
表观遗传学
人口
癌症
基因型
突变
基因
医学
环境卫生
作者
Genta Sawada,Atsushi Niida,Ryutaro Uchi,Hidenari Hirata,Teppei Shimamura,Yutaka Suzuki,Yuichi Shiraishi,Kenichi Chiba,Seiya Imoto,Yusuke Takahashi,Takeshi Iwaya,Tomoya Sudo,Tomoatsu Hayashi,Hiroki Takai,Yoshihiro Kawasaki,Takashi Matsukawa,Hidetoshi Eguchi,K Sugimachi,Fumiaki Tanaka,Hiromichi Suzuki
出处
期刊：Gastroenterology
[Elsevier BV]
日期：2016-02-10
卷期号：150 (5): 1171-1182
被引量：332
标识
DOI：10.1053/j.gastro.2016.01.035
摘要
We associated environmental and genetic factors with base substitution patterns of somatic mutations and provide a registry of genes and pathways that are disrupted in ESCCs. These findings might be used to design specific treatments for patients with esophageal squamous cancers.
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