Intramolecular Proximity-Induced Amplification for Accurate Imaging of Glycosylated RNAs in Living Cells and Zebrafish

Employing its multisite cooperative recognition capacity and excellent capture performance, the IPIA strategy successfully mapped the spatiotemporal dynamics of glycoRNAs during zebrafish development, while also setting the stage for elucidating their roles in organogenesis. The IPIA strategy provides a new tool for unveiling the roles of glycoRNAs in critical biological events and exploring their potential applications in disease diagnosis and therapy.