Recent Advances in the Characterization of Burkholderia Gladioli Pv. Cocovenenans and Its Toxin Production

ABSTRACTABSTRACTBurkholderia gladioli pv. cocovenenans (B. cocovenenans) and its lethal toxin, bongkrekic acid (BA), have been causing frequent incidents of food poisoning in China, resulting in increased attention. The toxin is produced by B. cocovenenans under appropriate temperature and humidity, and mainly targets the inner mitochondrial membrane to cause toxic effects. At present, there are methods available for detecting BA, but the detoxification mechanism is not perfect. This review summarizes the naming process, biological characteristics, toxin production conditions, and sources of B. cocovenenans, as well as the physical and chemical properties, poisoning mechanism, clinical presentation, detection methods, and detoxification of BA. Additionally, the review provides recommendations for preventing bongkrekic acid poisoning.KEYWORDS: B. cocovenenansbongkrekic acidtoxin productionresearch progresspoisoning mechanism AcknowledgmentsThis work is supported by the National Key R&D Program of China (No. 2022YFD1301003).Disclosure statementNo potential conflict of interest was reported by the authors.Additional informationFundingThe work was supported by the the National Key R&D Program of China [2022YFD1301003].