转染
腹膜腔
肿瘤坏死因子α
细胞凋亡
医学
转移
癌症研究
腹膜
化疗
免疫学
病理
生物
内科学
细胞培养
癌症
外科
生物化学
遗传学
作者
Nasha Qiu,Zhen Zhang,Xuyong Wei,Xu Chen,Xiaolong Jia,Kai Wang,Yunqi Chen,Shuai Wang,Renyi Su,Beini Cen,Youqing Shen,Chunying Chen,Yanpeng Liu,Xiao Xu
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-07-11
卷期号:23 (17): 7859-7868
被引量:1
标识
DOI:10.1021/acs.nanolett.3c01568
摘要
Peritoneal metastasis is very common in gastrointestinal, reproductive, and genitourinary tract cancers in late stages or postsurgery, causing poor prognosis, so effective and nontoxic prophylactic strategies against peritoneal metastasis are highly imperative. Herein, we demonstrate the first gene transfection as a nontoxic prophylaxis preventing peritoneal metastasis or operative metastatic dissemination. Lipopolyplexes of TNF-related-apoptosis-inducing-ligand (TRAIL) transfected peritonea and macrophages to express TRAIL for over 15 days. The expressed TRAIL selectively induced tumor cell apoptosis while exempting normal tissue, providing long-term tumor surveillance. Therefore, tumor cells inoculated in the pretransfected peritoneal cavity quickly underwent apoptosis and, thus, barely formed tumor nodules, significantly prolonging the mouse survival time compared with chemotherapy prophylaxis. Furthermore, lipopolyplex transfection showed no sign of toxicity. Therefore, this peritoneal TRAIL-transfection is an effective and safe prophylaxis, preventing peritoneal metastasis.
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