CaO 2 -Powered Nanomotors with Enhanced Cellular Uptake and Lysosomal Escape for Cuproptosis and Reactive Oxygen Species-Mediated Synergistic Cancer Therapy

accumulation, leading to calcification, mitochondrial dysfunction, and ROS imbalance, ultimately inducing tumor cell death. Moreover, these self-propelled nanomotors demonstrate superior tumor penetration and accumulation, as evidenced by robust antitumor efficacy in both in vitro and in vivo studies. Collectively, the self-propelled nanomotor system represents a promising method for improving intratumoral delivery and ROS generation, thereby enhancing the therapeutic outcomes of chemodynamic therapy.