Tetra Butyl Ammonium Fluoride: TBAF

Tetra butyl ammonium fluoride (TBAF) has been used widely as a reagent for the efficient cleavage of various silyl protecting groups from O-silylated nucleosides [1] [2] and pyrophosphates, [3] as well as N-silyl, [4] and S- silyl derivatives. [5] These reactions are carried out under very mild conditions in excellent yields.