Determination of Matrine Residue in Date by UPLC–MS/MS

A UPLC-MS/MS method was developed for the determination of matrine residue in date. The samples was extracted by acetonitrile, matrine residue identification was achieved by electrospray ionization in positive mode (ESI +), using multiple reaction monitoring (MRM). The limit of detection was 0.6 μg/kg. The average spiked recoveries in the range of 87.3-101.6%. The RSDs were 1.2-5.0%.