化学
齐拉西酮
部
色谱法
立体化学
抗精神病药
精神分裂症(面向对象编程)
计算机科学
程序设计语言
作者
Sunil Ramrao Murkute,Girij Pal Singh,SG Vasantharaju,Krishnamurthy Bhat,Himanshu M. Godbole,Pritesh R. Upadhyay,Anurag Trivedi
标识
DOI:10.1016/j.jpba.2021.114416
摘要
Ziprasidone hydrochloride is a second-generation antipsychotic drug employed for the treatment of schizophrenia and acute mania or mixed episodes associated with bipolar disorder. During the scale-up of ziprasidone hydrochloride, an unknown impurity was observed in the batches ranging from 0.10% to 0.15% by HPLC-UV analysis. The structure of an unknown impurity was proposed as 3,3'-methylenebis(5-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6-chloroindolin-2-one) which is named as methylene ziprasidone dimer (MZD impurity). It was isolated from an enriched sample by preparative HPLC, and its structure was elucidated by comprehensive analysis of HRMS, 1D NMR (1H, 13C), DEPT-135, 2D NMR (COSY, HSQC, HMBC) spectroscopy. A plausible mechanism for the formation of isolated impurity is proposed.
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