下调和上调
脂肪生成
竞争性内源性RNA
白色脂肪组织
衰老
脂肪组织
内科学
细胞生物学
新陈代谢
生物
长非编码RNA
基因
脂质代谢
内分泌学
生物化学
医学
作者
Yaqi Hu,Yifan Zhang,Shuwen Wang,Qianqian Wang,Quan Yuan,Wei Wu,Yonghao Gui,Jiale Zhao,Xueqing Li,Yumin He,Chengfu Yuan
出处
期刊:The Journals of Gerontology
[Oxford University Press]
日期:2024-02-27
标识
DOI:10.1093/gerona/glae066
摘要
Abstract Recent scientific studies have highlighted the importance of long chain non-coding RNAs (lncRNAs) in a variety of metabolic diseases, but the specific functions and mechanisms of lncRNAs in aberrant lipid synthesis associated with aging are unknown. In this work, we inspected the effects of lncRNAs on the lipid metabolism in aging mice, as substantial evidence suggests that aging disturbs lipid metabolism. The results revealed that the expression of lncRNA Gm15232 was significantly elevated in the epididymal white adipose tissue (eWAT) of aging mice compared to adult mice. This upregulation of Gm15232 functioned as a competitive endogenous RNA (ceRNA) by inhibiting the expression of miR-192-3p, and the ensuing downregulation of miR-192-3p increased the expression of the glucocorticoid receptor gene (GCR), which ultimately stimulated fat synthesis. The upregulation of Gm15232 thus increased lipogenesis through this mechanism. This study reveals a potential target for the treatment of age-related abnormalities of lipid metabolism.
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