Targeting MT‐tsRNA IDDMT with Nanoparticles to Annulus Fibrosus: A Novel Therapeutic Approach for Intervertebral Disc Degeneration

), capable of dual-modal imaging with MRI and NIR II, for targeted delivery of IDDMT inhibitors to repair AF damage and slow the progression of IDD is developed. In vitro and in vivo experiments have confirmed the effectiveness of UMZG in restoring mitochondrial dynamics, reducing ROS production, inflammation, and cell apoptosis. This innovative therapeutic approach, which integrates dual-modal imaging capabilities, offers a new avenue for the early treatment of IDD.