For pressure drop reduction and collecting efficiency incretion of the air filter,using computational fluid dynamics(CFD) simulation technology and combineing with the way of experimental test,particles trajectories and distribution rate of deposition in air filters were calculated simulatively,the position where the particles reside easily was obtained.According to experimental data of collecting efficiency,multi-relation calculation formula of filtration media collecting efficiency was proposed.By building 2D and 3D model of CFD,flow field distribution and filtration pressure drop of air filters were simulated,the results of computer simulation were in agreement with experimental test results basically.Using simulation model and changing structural parameters of air filters to instead parts of experimental research,variation and formula of relationship between the filtration pressure drop and its significant single-factor impact of air filters were obtained.Based on a large number of simulation data,multi-relation calculation formula of relationship between the pressure drop and its structural parameters of air filters was proposed using regression analysis.