一氧化氮
癌症治疗
纳米技术
癌症治疗
癌症
医学
神经科学
计算机科学
癌症研究
生物
材料科学
内科学
作者
Wan Huang,Jun Zhang,Li Luo,Yinglan Yu,Taolei Sun
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2022-12-28
卷期号:9 (1): 139-152
被引量:6
标识
DOI:10.1021/acsbiomaterials.2c01247
摘要
As an important endogenous signaling molecule, nitric oxide (NO) is involved in various physiological and pathological activities in living organisms. It is proved that NO plays a critical role in tumor therapy, while the extremely short half-life and nonspecific distribution of NO greatly limit its further clinical applications. Thus, the past few decades have witnessed the progress made in conquering these shortcomings, including developing innovative NO donors, especially smart and multimodal nanoplatforms. These platforms can precisely control the spatiotemporal distribution of therapeutic agents in the organism, which make big differences in tumor treatment. Here current NO therapeutic mechanisms for cancer, NO donors from small molecules to smart-responsive nanodrug delivery platforms, and NO-based combination therapy are comprehensively reviewed, emphasizing outstanding breakthroughs in these fields and hoping to bring new insights into NO-based tumor treatments.
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