Comparison of Bisoprolol and Metoprolol for Aortic Dissection

Objective To investigate the influences of different types of β-receptor blockers on heart rate and blood pressure and their side effects in patients with aortic dissection.Methods Seventytwo patients were randomly assigned to receive either metoprolol(25-50 mg·d-1, metoprolol group, n=37)or bisoprolol(5-15 mg·d-1, bisoprolol group, n=35) orally for 12 months. The heart rate, blood pressure and complications(bradyarrhythmia, conduction block, drug-induced hypotension, cardiac insufficiency,aggravation of cardiac insufficiency, etc.) were observed after treatment in both groups. Results The proportions of patients achieving heart rate and blood pressure targets were, respectively, 89.2% and86.5% in metoprolol group, and 91.4% and 83.2% in bisoprolol group. There were no significant differences between the two groups(P0.05).No bradyarrhythmia, conduction block, drug-induced hypotension, cardiac insufficiency, aggravation of cardiac insufficiency and other complications occurred in both groups. Conclusion The bisoprolol is superior to metoprolol for controlling heart rate, but inferior to metoprolol for controlling blood pressure. However, the differences in efficacies were not significant between bisoprolol and metoprolol.