A validated liquid chromatography-tandem mass spectrometric method for the determination of co-administered ranitidine and metronidazole in plasma of human volunteers

This work describes the development, optimization and validation of a liquid chromatography-tandem mass spectrometric method (LC-MS/MS) for the simultaneous analysis of co-administered ranitidine (RAN) and metronidazole (MET) in plasma of healthy human volunteers.